Real Academia de Medicina de Tenerife
Net Efficacy Adjusted for Risk (NEAR)

Net Efficacy Adjusted for Risk (NEAR)

Briefly, the NEAR (acronym of "Net Efficacy Adjusted for Risk") is a statistical formula to compare benefit/risk ratio of two alternative treatments using the results of clinical trials. It’s based on the comparison of the number of patients who are improved by each treatment and do not suffer adverse reactions (ADR). As the publication of clinical trials fails to report this data making it virtually impossible to obtain, we've proposed to use the calculation of the expected frequency instead.
Theoretical bases and practices are detailed in the following publication:
Boada JN, Boada C, García-Sáiz M, García M, Fernández E, et al. (2008) Net Efficacy Adjusted for Risk (NEAR): A Simple Procedure for Measuring Risk:Benefit Balance. PLoS ONE 3(10): e3580. doi:10.1371/journal.pone.0003580.

The web app hosted in this site lets you calculate the NEAR and its graphical representation, also showing the "traditional" efficacy and safety calculations for the same set of data. Just fill in the entries on the left and click on the "calculate" button.

This web app runs locally in your browser, so no data whatsoever will be sent or processed by our server. However, exporting the charts to a format of your choice (png, jpg, pdf…) requires interaction with an external server to process your petition. This interaction does not require the storage of any information at all in the remote server, as it's done on-the-fly. However, exporting to PDF require the data to be saved during a short period of time (a matter of seconds) in the remote server. You can check the exact terms of privacy regarding exporting options here